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It organizes courses, workshops and conferences, publishes four scientific journals and supports individual scientists and projects.
The "Young Investigator Program" which awards grants to young professors was established in 2000 and three additional journals were launched in 2000 (EMBO Reports), 2005 (Molecular Systems Biology) and 2008 (EMBO Molecular Medicine).
D., a postdoctoral researcher in the laboratory of CSHL Professor David Tuveson, M. D., looked closely at cells sampled from 308 people with pancreatic cancer, one of the most lethal malignancies, with a 5-year survival rate of only 8%. This enabled Feigin and colleagues including computational biologist Tyler Garvin, Ph.
D., formerly of Adjunct Associate Professor Michael Schatz's lab, to focus narrowly on genome segments called gene promoters.
"Promoters are important in determining when specific genes are turned on and off," says Feigin, "and I became interested in figuring out whether mutations within promoters -- as opposed to within the genes they regulate -consistently affects the way cancers develop and sustain themselves." The team "looked all across the genome," Feigin says, "and, interestingly, while we did find mutations in promoters, we never found clusters of these mutations near any of the genes that prior research had already told us were typically mutated in pancreatic cancer." Genes called KRAS and p53 are mutated in the majority of pancreas cancer cells, for example.
But mutations in promoters sifted out of mountains of data by the team's novel mathematical formula, or algorithm, called GECCO, lay in genes never before implicated in pancreatic cancer.
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